منابع مشابه
Intestinal Master Transcription Factor Cdx2 Controls Chromatin 1 Access for Partner Transcription Factor Binding 2 3
1 Intestinal master transcription factor CDX2 controls chromatin 1 access for partner transcription factor binding 2 3 Michael P. Verzi*, Hyunjin Shin*, Adrianna K. San Roman, 4 X. Shirley Liu, and Ramesh A. Shivdasani 5 6 7 Department of Medical Oncology and Department of Biostatistics and Computational Biology, 8 Dana-Farber Cancer Institute, Boston, MA 02215 (USA); Departments of Medicine, B...
متن کاملNovel Nucleotide Variations, Haplotypes Structure and Associations with Growth Related Traits of Goat AT Motif-Binding Factor (ATBF1) Gene
The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is required for early activation of the pituitary specific transcription factor 1 (Pit1) gene (also known as POU1F1) critically affecting mammali...
متن کاملQuantitative transcription factor binding kinetics at the single-molecule level.
We investigated the binding interaction between the bacteriophage lambda-repressor CI and its target DNA using total internal reflection fluorescence microscopy. Large stepwise changes in the intensity of the red fluorescent protein fused to CI were observed as it associated with and dissociated from individually labeled single-molecule DNA targets. The stochastic association and dissociation w...
متن کاملCharacterization of Nuclear Localization and SUMOylation of the ATBF1 Transcription Factor in Epithelial Cells
ATBF1/ZFHX3 is a large transcription factor that functions in development, tumorigenesis and other biological processes. ATBF1 is normally localized in the nucleus, but is often mislocalized in the cytoplasm in cancer cells. The mechanism underlying the mislocalization of ATBF1 is unknown. In this study, we analyzed the nuclear localization of ATBF1, and found that ectopically expressed ATBF1 f...
متن کاملCREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites.
The transcription factor GATA-1 is a key regulator of erythroid-cell differentiation and survival. We have previously shown that the transcriptional cofactor CREB-binding protein (CBP) binds to the zinc finger domain of GATA-1, markedly stimulates the transcriptional activity of GATA-1, and is required for erythroid differentiation. Here we report that CBP, but not p/CAF, acetylates GATA-1 at t...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2011
ISSN: 1768-3262
DOI: 10.4267/2042/38035